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Discuss the process that gives rise to the base and facial bones of the skull. The facial bones and base of the skull arise via the process of endochondral ossification. This process begins with the localized accumulation of mesenchyme tissue at the sites of the future bones. The mesenchyme differentiates into hyaline cartilage, which forms a cartilage model of the future bone. The cartilage allows for growth and enlargement of the model.